Should take you about five hours all told i believe. An alternate route you can check out would go from Como via Lugano to Zurich and then to Interlaken. www.bahn.de will tell the best route. As
Set out for Lake Como today, driving along the Riviera coast and passing through Genoa and Milan on your way. You'll start at Piazza Cavour, in Como’s historical center, before taking a semi-private cruise around the lake. You'll see why Lake Como has been attracting nobility since Roman times when Julius Caesar founded Novum Comum (Como city vE7Tlbz.